Ultrasound and microbubble-targeted delivery of therapeutic compounds
نویسندگان
چکیده
منابع مشابه
Myocardial delivery of colloid nanoparticles using ultrasound-targeted microbubble destruction.
AIMS Ultrasound (US)-targeted microbubble destruction (UTMD) is a promising method for delivering genetic material to the heart. The aim of this study was: (i) to test whether colloid nanoparticles can be delivered to the rat myocardium using UTMD; and (ii) to determine whether tissue damage and contractile dysfunction occurs in hearts exposed to UTMD in vivo. METHODS AND RESULTS Hearts from ...
متن کاملUltrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formation.
Contrast microbubbles in combination with ultrasound (US) are promising vehicles for local drug and gene delivery. However, the exact mechanisms behind intracellular delivery of therapeutic compounds remain to be resolved. We hypothesized that endocytosis and pore formation are involved during US and microbubble targeted delivery (UMTD) of therapeutic compounds. Therefore, primary endothelial c...
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Recombinant adeno-associated viral (rAAV) vectors are potentially powerful tools for gene therapy of CNS diseases, but their penetration into brain parenchyma is severely limited by the blood-brain barrier (BBB) and current delivery relies on invasive stereotactic injection. Here we evaluate the local, targeted delivery of rAAV vectors into the brains of mice by noninvasive, reversible, microbu...
متن کاملUltrasound-microbubble targeted delivery of ICAM-1 in mouse model of peripheral arterial disease
Background/introduction Peripheral arterial disease (PAD) affects 12 million people in the United States. Unfortunately, current treatments are highly invasive and have limited efficacy. Ultrasound (US) in conjunction with microbubbles (MB) has recently been explored as a non-invasive strategy for the delivery of intravascularly circulating therapeutic agents. US mediated MB oscillation can lea...
متن کاملUltrasound Targeted Microbubble Destruction Stimulates Cellular Endocytosis in Facilitation of Adeno-Associated Virus Delivery
The generally accepted mechanism for ultrasound targeted microbubble destruction (UTMD) to enhance drug and gene delivery is through sonoporation. However, passive uptake of adeno-associated virus (AAV) into cells following sonoporation does not adequately explain observations of enhanced transduction by UTMD. This study investigated alternative mechanisms of UTMD enhancement in AAV delivery. U...
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ژورنال
عنوان ژورنال: Netherlands Heart Journal
سال: 2009
ISSN: 1568-5888,1876-6250
DOI: 10.1007/bf03086223